TY - JOUR
T1 - Inhibition of phosphatidylinositol kinase by toyocamycin
AU - Nishioka, Hiroshi
AU - Sawa, Tsutomu
AU - Hamada, Masa
AU - Shimura, Naomi
AU - Imoto, Masaya
AU - Umezawa, Kazuo
PY - 1990
Y1 - 1990
N2 - We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 μg/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.
AB - We have screened toyocamycin as an inhibitor of phosphatidylinositol kinase. It inhibited the enzyme of A431 cell membrane with an IC50 of 3.3 μg/ml. Adenosine and formycin A also inhibited the enzyme, but other 6 related nucleosides did not. Although orobol and 2,3-dihydroxybenzaldehyde that inhibit phosphatidylinositol kinase inhibited in situ phosphatidylinositol turnover, toyocamycin did not.
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U2 - 10.7164/antibiotics.43.1586
DO - 10.7164/antibiotics.43.1586
M3 - Article
C2 - 2177464
AN - SCOPUS:0025601414
SN - 0021-8820
VL - 43
SP - 1586
EP - 1589
JO - The Journal of Antibiotics
JF - The Journal of Antibiotics
IS - 12
ER -