Inhibition of Prostaglandin Biosynthesis by the Constituents of Medicinal Plants

Fumiyuki Kiuchi, Masaaki Shibuya, Takeshi Kinoshita, Ushio Sankawa

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Hot aqueous extracts of medicinal plants used in oriental medicine were tested for inhibitory effect on prostaglandin biosynthesis in order to detect biologically active compounds present therein. Of 162 samples tested, 35 showed significant inhibition. Inhibitors of prostaglandin biosynthesis contained in Cyperus rotundus were identified as sesquiterpenes. a-Cyperone, the main inhibitor of C. rotundus, showed competitive-type inhibition with respect to the substrate, arachidonic acid.

Original languageEnglish
Pages (from-to)3391-3396
Number of pages6
JournalChemical and Pharmaceutical Bulletin
Issue number10
Publication statusPublished - 1983
Externally publishedYes


  • Cyperus rotundus α-cyperone
  • biosynthesis
  • inhibitor
  • oriental medicine
  • prostaglandin

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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