Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin

Masaya Imoto, Takeshi Nakamura, Shin Ichiro Tanaka, Kazuo Umezawa

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Erbstatin, a tyrosine kinase inhibitor, inhibited p59fyn- and p56lck-kinases in vitrowith IC50s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, was also inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.

Original languageEnglish
Pages (from-to)1700-1701
Number of pages2
JournalBioscience, Biotechnology, and Biochemistry
Issue number9
Publication statusPublished - 1994
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry


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