Inhibitors of prostaglandin biosynthesis from Alpinia officinarum

Fumiyuki Kiuchi; Masaaki Shibuya; Ushio Sankawa

doi:10.1248/cpb.30.2279

Inhibitors of prostaglandin biosynthesis from Alpinia officinarum

Fumiyuki Kiuchi, Masaaki Shibuya, Ushio Sankawa

Research output: Contribution to journal › Article › peer-review

83 Citations (Scopus)

Abstract

Three new diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia officinarum Hance. Their structures were elucidated to be 7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3,5-heptadione (I), 5-methoxy-7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3-heptanone (IV), and 5-hydroxy-7-(4″-hydroxyphenyl)-l-phenyl-3-heptanone (VI) by the interpretation of spectral data.

Original language	English
Pages (from-to)	2279-2282
Number of pages	4
Journal	Chemical and Pharmaceutical Bulletin
Volume	30
Issue number	6
DOIs	https://doi.org/10.1248/cpb.30.2279
Publication status	Published - 1982
Externally published	Yes

Keywords

Alpinia officinarum
Alpinia oxyphilla
Zingiberaceae
biosynthesis
diarylheptanoid
inhibitor
prostaglandin

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.30.2279

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title = "Inhibitors of prostaglandin biosynthesis from Alpinia officinarum",

abstract = "Three new diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia officinarum Hance. Their structures were elucidated to be 7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3,5-heptadione (I), 5-methoxy-7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3-heptanone (IV), and 5-hydroxy-7-(4″-hydroxyphenyl)-l-phenyl-3-heptanone (VI) by the interpretation of spectral data.",

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T1 - Inhibitors of prostaglandin biosynthesis from Alpinia officinarum

AU - Kiuchi, Fumiyuki

AU - Shibuya, Masaaki

AU - Sankawa, Ushio

PY - 1982

Y1 - 1982

N2 - Three new diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia officinarum Hance. Their structures were elucidated to be 7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3,5-heptadione (I), 5-methoxy-7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3-heptanone (IV), and 5-hydroxy-7-(4″-hydroxyphenyl)-l-phenyl-3-heptanone (VI) by the interpretation of spectral data.

AB - Three new diarylheptanoids were isolated as inhibitors of prostaglandin biosynthesis from the methanol extract of Alpinia officinarum Hance. Their structures were elucidated to be 7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3,5-heptadione (I), 5-methoxy-7-(4″-hydroxy-3″-methoxyphenyl)-l-phenyl-3-heptanone (IV), and 5-hydroxy-7-(4″-hydroxyphenyl)-l-phenyl-3-heptanone (VI) by the interpretation of spectral data.

KW - Alpinia officinarum

KW - Alpinia oxyphilla

KW - Zingiberaceae

KW - biosynthesis

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KW - inhibitor

KW - prostaglandin

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JO - Chemical and Pharmaceutical Bulletin

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Inhibitors of prostaglandin biosynthesis from Alpinia officinarum

Abstract

Keywords

ASJC Scopus subject areas

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