Inhibitory effect of aspirin on inflammation-induced lung metastasis of cancer cells associated with neutrophil infiltration

Erica Nishimura, Kazumasa Fukuda, Satoru Matsuda, Ryota Kobayashi, Kazuaki Matsui, Masashi Takeuchi, Koshu Okubo, Junichi Hirahashi, Rieko Nakamura, Hirofumi Kawakubo, Yuko Kitagawa

Research output: Contribution to journalArticlepeer-review


Purpose: Systematic inflammation has been reported to contribute to cancer progression through various mechanisms; however, the exact mechanism is still the subject of research. In this study, we evaluated the influence of systematic inflammation on lung metastasis, using a murine abdominal sepsis model, and assessed its relationship with pneumonia after curative esophagectomy in patients with esophageal cancer. Methods: We used a murine abdominal sepsis model given highly metastatic osteosarcoma, to reveal the mechanism of systematic inflammation and its potential for lung metastasis. The therapeutic effect of aspirin (ASA) in preventing distant metastasis was also investigated. Subsequently, we analyzed, retrospectively, the relationship between pneumonia and lung metastasis after esophagectomy in patients who underwent esophagectomy at Keio University between January, 2007 and October, 2020. Results: Abdominal sepsis provoked lung injury in the acute phase. ASA inhibited the recruitment of neutrophils triggered by the lung injury, and it also suppressed lung metastasis. Our retrospective study revealed that lung metastasis was more frequent in patients with postoperative pneumonia. Conclusions: Postoperative acute lung injury is associated with a higher risk of lung metastasis. ASA may be a potential preoperative treatment for inhibiting lung metastasis by preventing the recruitment of neutrophils.

Original languageEnglish
Pages (from-to)973-983
Number of pages11
JournalSurgery today
Issue number8
Publication statusPublished - 2023 Aug


  • Aspirin
  • Lung inflammation
  • Lung metastasis
  • Sepsis

ASJC Scopus subject areas

  • Surgery


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