@article{cc3823135ca148e6bdaa8629756bf298,
title = "Inhibitory effect of brain natriuretic peptide on central angiotensin II-stimulated pressor response in conscious rats",
abstract = "The effect of intracerebroventricular injection of brain natriuretic peptide (BNP) on blood pressure and heart rate was studied in conscious, unrestrained rats. The intracerebroventricular (i.c.v.) injection of BNP did not affect basal blood pressure and heart rate, but it attenuated i.c.v. angiotensin II (AII)-induced pressor response in a dose-dependent manner. These results suggest that BNP plays a role in the regulation of blood pressure in the central nervous system.",
keywords = "Angiotensin II, Atrial natriuretic peptide, Blood pressure, Brain natriuretic peptide, Heart rate",
author = "Gotaro Shirakami and Kazuwa Nakao and Takayuki Yamada and Hiroshi Itoh and Kenjiro Mori and Kenji Kangawa and Naoto Minamino and Hisayuki Matsuo and Hiroo Imura",
note = "Funding Information: We thank Mrs. Hiroko Tabata, Miss Atsuko Furu and Miss Ikuyo Yoshida for the secretarial assistance. This work was supported in part by research grants from the Japanese Ministry of Education, Science and Culture, the Japanese Ministry of Health and Welfare 'Disorders of Adrenal Hormone' Research Committee, Japan, 1987, Life Science Research Project of Institute of Physical and Chemical Research (RIKEN), Japan Tobacco Inc. and the Yamanouchi Foundation for Research on Metabolic Disorders, by research grants for cardiovascular diseases ((60A-3) and 62A'-1)) from the Japanese Ministry of Health and Welfare.",
year = "1988",
month = aug,
day = "15",
doi = "10.1016/0304-3940(88)90252-2",
language = "English",
volume = "91",
pages = "77--83",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "Elsevier Ireland Ltd",
number = "1",
}