Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

Osamu Ohno; Taeko Watabe; Kazuhiko Nakamura; Masaru Kawagoshi; Nobuo Uotsu; Tomohiro Chiba; Masayoshi Yamada; Kohji Yamaguchi; Kaoru Yamada; Kenji Miyamoto; Daisuke Uemura

doi:10.1271/bbb.100221

Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

Osamu Ohno, Taeko Watabe, Kazuhiko Nakamura, Masaru Kawagoshi, Nobuo Uotsu, Tomohiro Chiba, Masayoshi Yamada, Kohji Yamaguchi, Kaoru Yamada, Kenji Miyamoto, Daisuke Uemura

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

Original language	English
Pages (from-to)	1504-1506
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	74
Issue number	7
DOIs	https://doi.org/10.1271/bbb.100221
Publication status	Published - 2010

Keywords

Bakuchiol
Bavachin
Isobavachalcone
Melanin
Piper longum

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.100221

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Ohno, O., Watabe, T., Nakamura, K., Kawagoshi, M., Uotsu, N., Chiba, T., Yamada, M., Yamaguchi, K., Yamada, K., Miyamoto, K., & Uemura, D. (2010). Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells. Bioscience, Biotechnology and Biochemistry, 74(7), 1504-1506. https://doi.org/10.1271/bbb.100221

Ohno, O, Watabe, T, Nakamura, K, Kawagoshi, M, Uotsu, N, Chiba, T, Yamada, M, Yamaguchi, K, Yamada, K, Miyamoto, K & Uemura, D 2010, 'Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells', Bioscience, Biotechnology and Biochemistry, vol. 74, no. 7, pp. 1504-1506. https://doi.org/10.1271/bbb.100221

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abstract = "An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.",

keywords = "Bakuchiol, Bavachin, Isobavachalcone, Melanin, Piper longum",

author = "Osamu Ohno and Taeko Watabe and Kazuhiko Nakamura and Masaru Kawagoshi and Nobuo Uotsu and Tomohiro Chiba and Masayoshi Yamada and Kohji Yamaguchi and Kaoru Yamada and Kenji Miyamoto and Daisuke Uemura",

note = "Funding Information: This work was supported in part by the Japanese Society for the Promotion of Science by Grants-in-Aid for Scientific Research (21221009 and 20611006).",

year = "2010",

doi = "10.1271/bbb.100221",

language = "English",

volume = "74",

pages = "1504--1506",

journal = "Bioscience, Biotechnology and Biochemistry",

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T1 - Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

AU - Ohno, Osamu

AU - Watabe, Taeko

AU - Nakamura, Kazuhiko

AU - Kawagoshi, Masaru

AU - Uotsu, Nobuo

AU - Chiba, Tomohiro

AU - Yamada, Masayoshi

AU - Yamaguchi, Kohji

AU - Yamada, Kaoru

AU - Miyamoto, Kenji

AU - Uemura, Daisuke

N1 - Funding Information: This work was supported in part by the Japanese Society for the Promotion of Science by Grants-in-Aid for Scientific Research (21221009 and 20611006).

PY - 2010

Y1 - 2010

N2 - An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

AB - An EtOH extract of fruits of Piper longum was found to exhibit a potent inhibitory effect against a-melano-cyte-stimulating hormone (α-MSH)- induced melanin production in B16 mouse melanoma cells. Bioassay-directed fractionation led to the isolation of prenylated phenolic compounds bakuchiol, bavachin, and isobava-chalcone. These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin.

KW - Bakuchiol

KW - Bavachin

KW - Isobavachalcone

KW - Melanin

KW - Piper longum

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Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from piper longum on melanin production in b16 mouse melanoma cells

Abstract

Keywords

ASJC Scopus subject areas

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