Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy

Shigeaki Suzuki; Shigeru Nogawa; Kortaro Tanaka; Atsuo Koto; Yasuo Fukuuchi; Masataka Kuwana

doi:10.1016/S0303-8467(03)00061-1

Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy

Shigeaki Suzuki, Shigeru Nogawa, Kortaro Tanaka, Atsuo Koto, Yasuo Fukuuchi, Masataka Kuwana

Department of Internal Medicine (Neurology)

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.

Original language	English
Pages (from-to)	16-18
Number of pages	3
Journal	Clinical Neurology and Neurosurgery
Volume	106
Issue number	1
DOIs	https://doi.org/10.1016/S0303-8467(03)00061-1
Publication status	Published - 2003 Dec

Keywords

HLA class II
Myasthenia gravis
Pure red cell aplasia
Thymectomy

ASJC Scopus subject areas

Surgery
Clinical Neurology

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10.1016/S0303-8467(03)00061-1

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title = "Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy",

abstract = "Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.",

keywords = "HLA class II, Myasthenia gravis, Pure red cell aplasia, Thymectomy",

author = "Shigeaki Suzuki and Shigeru Nogawa and Kortaro Tanaka and Atsuo Koto and Yasuo Fukuuchi and Masataka Kuwana",

note = "Funding Information: The authors thank Kyoko Kimura for her expert technical assistance and Drs. Masafumi Kawamura and Makoto Sawafuzi for their helpful suggestions. This work was supported by a grant from Japanese Ministry of Education, Science, Sports and Culture.",

year = "2003",

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doi = "10.1016/S0303-8467(03)00061-1",

language = "English",

volume = "106",

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journal = "Clinical Neurology and Neurosurgery",

issn = "0303-8467",

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T1 - Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy

AU - Suzuki, Shigeaki

AU - Nogawa, Shigeru

AU - Tanaka, Kortaro

AU - Koto, Atsuo

AU - Fukuuchi, Yasuo

AU - Kuwana, Masataka

N1 - Funding Information: The authors thank Kyoko Kimura for her expert technical assistance and Drs. Masafumi Kawamura and Makoto Sawafuzi for their helpful suggestions. This work was supported by a grant from Japanese Ministry of Education, Science, Sports and Culture.

PY - 2003/12

Y1 - 2003/12

N2 - Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.

AB - Pure red cell aplasia (PRCA) is well known to be concomitant with myasthenia gravis (MG), but it is difficult to predict the development of PRCA in patients with MG. Of 135 patients with MG, four (2.9%) had PRCA. All patients developed PRCA after thymectomy during a period when MG was in remission. The frequencies of thymoma, bulbar involvement and high anti-acetylcholine receptor (AChR) antibody levels were significantly higher in four patients with PRCA. Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy.

KW - HLA class II

KW - Myasthenia gravis

KW - Pure red cell aplasia

KW - Thymectomy

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AN - SCOPUS:0344982901

SN - 0303-8467

VL - 106

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JO - Clinical Neurology and Neurosurgery

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IS - 1

ER -

Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy

Abstract

Keywords

ASJC Scopus subject areas

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