Injection laryngoplasty with BIOPEX®

Keisuke Okubo, Koichiro Saito, Takekatsu Fujimine, Akihiro Shiotani

Research output: Contribution to journalArticlepeer-review


Calcium phosphate bone paste (BIOPEX®) is a material for medical use that has a paste form when injected but changes with time to hydroxyapatite. BIOPEX® offers many advantages as a material for injection into the vocal fold: it induces only slight foreign-material reactions; material absorption is minimal over a long period; preparation is easy; injection is non-invasive, safe and cosmetically excellent; and its usage allows phonation, eating and discharge one day after operation. A basic indication for this operative technique is unilateral vocal fold paralysis. The material is injected into a site between the thyroarytenoid muscle and thyroid cartilage or into the thyroarytenoid muscle. In patients with a large posterior glottal gap, the material is also injected into the lateral side of the vocal process. In the 3.5 years since the initiation of this technique, we have treated 38 patients and observed favorable clinical courses, without BIOPEX® absorption, on CT images of all patients. We consider this operative technique, which aims at medial shift of the vocal fold by injection of a sclerotic agent into the lateral side of the vocal fold, as "type 1 thyroplasty performed from the pharyngeal lumen.".

Original languageEnglish
Pages (from-to)171-177
Number of pages7
JournalJapan Journal of Logopedics and Phoniatrics
Issue number2
Publication statusPublished - 2007 Apr


  • Injectable material for vocal fold
  • Injection laryngoplasty
  • Unilateral vocal fold paralysis

ASJC Scopus subject areas

  • LPN and LVN
  • Speech and Hearing


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