Innate lymphoid cells in organ fibrosis

Yohei Mikami, Yoshiaki Takada, Yuya Hagihara, Takanori Kanai

Research output: Contribution to journalShort surveypeer-review

20 Citations (Scopus)


Innate lymphoid cells (ILCs) are a recently identified family of lymphoid effector cells. ILCs are mainly clustered into 3 groups based on their unique cytokine profiles and transcription factors typically attributed to the subsets of T helper cells. ILCs have a critical role in the mucosal immune response through promptly responding to pathogens and producing large amount of effector cytokines of type 1, 2, or 3 responses. In addition to the role of early immune responses against infections, ILCs, particularly group 2 ILCs (ILC2), have recently gained attention for modulating remodeling and fibrosis especially in the mucosal tissues. Herein, we overview the current knowledge in this area, highlighting roles of ILCs on fibrosis in the mucosal tissues, especially focusing on the gut and lung. We also discuss some new directions for future research by extrapolating from knowledge derived from studies on Th cells.

Original languageEnglish
Pages (from-to)27-36
Number of pages10
JournalCytokine and Growth Factor Reviews
Publication statusPublished - 2018 Aug


  • Fibrosis
  • Inflammatory bowel disease
  • Innate lymphoid cells
  • Mucosal immunology
  • Pulmonary fibrosis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Immunology
  • General Biochemistry,Genetics and Molecular Biology


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