TY - JOUR
T1 - Innate lymphoid cells in organ fibrosis
AU - Mikami, Yohei
AU - Takada, Yoshiaki
AU - Hagihara, Yuya
AU - Kanai, Takanori
N1 - Funding Information:
The authors acknowledge Dr. Mizuno S (Keio University, Tokyo, Japan) for critical reading. This study was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI JSPS 15H02534 and AMED-CREST 16gm1010003h0001, 15H02534; Advanced Research and Development Programs for Medical Innovation (AMED-CREST; 16gm1010003h0001); and Keio University Medical Fund.
Funding Information:
The authors acknowledge Dr. Mizuno S (Keio University, Tokyo, Japan) for critical reading. This study was supported by Japan Society for the Promotion of Science (JSPS) KAKENHI JSPS 15H02534 and AMED-CREST 16gm1010003h0001, 15H02534; Advanced Research and Development Programs for Medical Innovation (AMED-CREST; 16gm1010003h0001); and Keio University Medical Fund.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2018/8
Y1 - 2018/8
N2 - Innate lymphoid cells (ILCs) are a recently identified family of lymphoid effector cells. ILCs are mainly clustered into 3 groups based on their unique cytokine profiles and transcription factors typically attributed to the subsets of T helper cells. ILCs have a critical role in the mucosal immune response through promptly responding to pathogens and producing large amount of effector cytokines of type 1, 2, or 3 responses. In addition to the role of early immune responses against infections, ILCs, particularly group 2 ILCs (ILC2), have recently gained attention for modulating remodeling and fibrosis especially in the mucosal tissues. Herein, we overview the current knowledge in this area, highlighting roles of ILCs on fibrosis in the mucosal tissues, especially focusing on the gut and lung. We also discuss some new directions for future research by extrapolating from knowledge derived from studies on Th cells.
AB - Innate lymphoid cells (ILCs) are a recently identified family of lymphoid effector cells. ILCs are mainly clustered into 3 groups based on their unique cytokine profiles and transcription factors typically attributed to the subsets of T helper cells. ILCs have a critical role in the mucosal immune response through promptly responding to pathogens and producing large amount of effector cytokines of type 1, 2, or 3 responses. In addition to the role of early immune responses against infections, ILCs, particularly group 2 ILCs (ILC2), have recently gained attention for modulating remodeling and fibrosis especially in the mucosal tissues. Herein, we overview the current knowledge in this area, highlighting roles of ILCs on fibrosis in the mucosal tissues, especially focusing on the gut and lung. We also discuss some new directions for future research by extrapolating from knowledge derived from studies on Th cells.
KW - Fibrosis
KW - Inflammatory bowel disease
KW - Innate lymphoid cells
KW - Mucosal immunology
KW - Pulmonary fibrosis
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U2 - 10.1016/j.cytogfr.2018.07.002
DO - 10.1016/j.cytogfr.2018.07.002
M3 - Short survey
C2 - 30104153
AN - SCOPUS:85051396459
SN - 1359-6101
VL - 42
SP - 27
EP - 36
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
ER -
