Inositol trisphosphate receptors in the vascular development

Keiko Uchida, Maki Nakazawa, Chihiro Yamagishi, Katsuhiko Mikoshiba, Hiroyuki Yamagishi

Research output: Chapter in Book/Report/Conference proceedingChapter


The placental circulation is crucial for the development of mammalian embryos [1]. The labyrinth layer in the placenta is created by extensive villous branching of the trophoblast and vascularization arising from the embryonic mesoderm. In the labyrinth, materials are exchanged between the maternal and embryonic circulation. Recently, we have found that inositol 1,4,5-trisphosphate (IP3) receptors (IP3Rs) may be required for the placental vascularization.

Original languageEnglish
Title of host publicationEtiology and Morphogenesis of Congenital Heart Disease
Subtitle of host publicationFrom Gene Function and Cellular Interaction to Morphology
PublisherSpringer Japan
Number of pages3
ISBN (Electronic)9784431546283
ISBN (Print)9784431546276
Publication statusPublished - 2016 Jan 1


  • Angiogenesis
  • Intracellular calcium
  • Placenta
  • Vascular development

ASJC Scopus subject areas

  • General Medicine
  • General Biochemistry,Genetics and Molecular Biology


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