Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda; Kotaro Soeda; Yukiko Okazaki; Naoki Kobayashi; Yukari Masuda; Naoko Arakawa; Hirotsugu Suwanai; Yosuke Masamoto; Yoshihiko Izumida; Nozomu Kamei; Takayoshi Sasako; Ryo Suzuki; Tetsuya Kubota; Naoto Kubota; Mineo Kurokawa; Kazuyuki Tobe; Tetsuo Noda; Kenya Honda; Domenico Accili; Toshimasa Yamauchi; Takashi Kadowaki; Kohjiro Ueki

doi:10.1016/j.molcel.2020.04.033

Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

Gotaro Toda, Kotaro Soeda, Yukiko Okazaki, Naoki Kobayashi, Yukari Masuda, Naoko Arakawa, Hirotsugu Suwanai, Yosuke Masamoto, Yoshihiko Izumida, Nozomu Kamei, Takayoshi Sasako, Ryo Suzuki, Tetsuya Kubota, Naoto Kubota, Mineo Kurokawa, Kazuyuki Tobe, Tetsuo Noda, Kenya Honda, Domenico Accili, Toshimasa YamauchiTakashi Kadowaki, Kohjiro Ueki

Department of Microbiology and Immunology

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Toda et al. demonstrate using conditional knockout models that IL-10 produced in macrophages in response to postprandial signals can cooperate with insulin to suppress hepatic gluconeogenic gene expression in vitro and in mice. This process is deficient in obese insulin-resistant mice and may be a potential therapeutic target.

Original language	English
Pages (from-to)	43-53.e4
Journal	Molecular Cell
Volume	79
Issue number	1
DOIs	https://doi.org/10.1016/j.molcel.2020.04.033
Publication status	Published - 2020 Jul 2

Keywords

Akt
gut microbiome
insulin
interleukin-10
lipopolysaccharide
macrophages
mammalian target of rapamycin
postprandial gluconeogenesis

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2020.04.033

Cite this

Toda, G., Soeda, K., Okazaki, Y., Kobayashi, N., Masuda, Y., Arakawa, N., Suwanai, H., Masamoto, Y., Izumida, Y., Kamei, N., Sasako, T., Suzuki, R., Kubota, T., Kubota, N., Kurokawa, M., Tobe, K., Noda, T., Honda, K., Accili, D., ... Ueki, K. (2020). Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation. Molecular Cell, 79(1), 43-53.e4. https://doi.org/10.1016/j.molcel.2020.04.033

Toda, G, Soeda, K, Okazaki, Y, Kobayashi, N, Masuda, Y, Arakawa, N, Suwanai, H, Masamoto, Y, Izumida, Y, Kamei, N, Sasako, T, Suzuki, R, Kubota, T, Kubota, N, Kurokawa, M, Tobe, K, Noda, T, Honda, K, Accili, D, Yamauchi, T, Kadowaki, T & Ueki, K 2020, 'Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation', Molecular Cell, vol. 79, no. 1, pp. 43-53.e4. https://doi.org/10.1016/j.molcel.2020.04.033

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title = "Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation",

abstract = "Toda et al. demonstrate using conditional knockout models that IL-10 produced in macrophages in response to postprandial signals can cooperate with insulin to suppress hepatic gluconeogenic gene expression in vitro and in mice. This process is deficient in obese insulin-resistant mice and may be a potential therapeutic target.",

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author = "Gotaro Toda and Kotaro Soeda and Yukiko Okazaki and Naoki Kobayashi and Yukari Masuda and Naoko Arakawa and Hirotsugu Suwanai and Yosuke Masamoto and Yoshihiko Izumida and Nozomu Kamei and Takayoshi Sasako and Ryo Suzuki and Tetsuya Kubota and Naoto Kubota and Mineo Kurokawa and Kazuyuki Tobe and Tetsuo Noda and Kenya Honda and Domenico Accili and Toshimasa Yamauchi and Takashi Kadowaki and Kohjiro Ueki",

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AU - Soeda, Kotaro

AU - Okazaki, Yukiko

AU - Kobayashi, Naoki

AU - Masuda, Yukari

AU - Arakawa, Naoko

AU - Suwanai, Hirotsugu

AU - Masamoto, Yosuke

AU - Izumida, Yoshihiko

AU - Kamei, Nozomu

AU - Sasako, Takayoshi

AU - Suzuki, Ryo

AU - Kubota, Tetsuya

AU - Kubota, Naoto

AU - Kurokawa, Mineo

AU - Tobe, Kazuyuki

AU - Noda, Tetsuo

AU - Honda, Kenya

AU - Accili, Domenico

AU - Yamauchi, Toshimasa

AU - Kadowaki, Takashi

AU - Ueki, Kohjiro

PY - 2020/7/2

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KW - gut microbiome

KW - insulin

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KW - mammalian target of rapamycin

KW - postprandial gluconeogenesis

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Insulin- and Lipopolysaccharide-Mediated Signaling in Adipose Tissue Macrophages Regulates Postprandial Glycemia through Akt-mTOR Activation

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Keywords

ASJC Scopus subject areas

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