Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb

Tomoko Kuwabara, Mohamedi N. Kagalwala, Yasuko Onuma, Yuzuru Ito, Masaki Warashina, Kazuyuki Terashima, Tsukasa Sanosaka, Kinichi Nakashima, Fred H. Gage, Makoto Asashima

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)


In the present study, we demonstrated that insulin is produced not only in the mammalian pancreas but also in adult neuronal cells derived from the hippocampus and olfactory bulb (OB). Paracrine Wnt3 plays an essential role in promoting the active expression of insulin in both hippocampal and OB-derived neural stem cells. Our analysis indicated that the balance between Wnt3, which triggers the expression of insulin via NeuroD1, and IGFBP-4, which inhibits the original Wnt3 action, is regulated depending on diabetic (DB) status. We also show that adult neural progenitors derived from DB animals retain the ability to give rise to insulin-producing cells and that grafting neuronal progenitors into the pancreas of DB animals reduces glucose levels. This study provides an example of a simple and direct use of adult stem cells from one organ to another, without introducing additional inductive genes. See accompanying article

Original languageEnglish
Pages (from-to)742-754
Number of pages13
JournalEMBO Molecular Medicine
Issue number12
Publication statusPublished - 2011 Dec
Externally publishedYes


  • Diabetes
  • Hippocampus
  • Insulin
  • Neural stem cell
  • Olfactory bulb

ASJC Scopus subject areas

  • Molecular Medicine


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