Integrin VLA-5 negative primary plasma cell leukemia

Ken ichi Ohtake, Tsutomu Takeuchi, Keiko Saito, Tatsuya Ito, Isao Ito, Kazutoshi Aoki, Yasuhide Takano, Koichi Amano, Osamu Hosono, Jim Koide, Tohru Abe, Hiroshi Suzuki

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5. (Internal Medicine 32: 565-568, 1993).

Original languageEnglish
Pages (from-to)565-568
Number of pages4
JournalInternal Medicine
Issue number7
Publication statusPublished - 1993
Externally publishedYes


  • CD38
  • VLA-4
  • benign monoclonal gammopathy
  • multiple myeloma

ASJC Scopus subject areas

  • Internal Medicine


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