Integrin VLA-5 negative primary plasma cell leukemia

Ken ichi Ohtake; Tsutomu Takeuchi; Keiko Saito; Tatsuya Ito; Isao Ito; Kazutoshi Aoki; Yasuhide Takano; Koichi Amano; Osamu Hosono; Jim Koide; Tohru Abe; Hiroshi Suzuki

doi:10.2169/internalmedicine.32.565

Integrin VLA-5 negative primary plasma cell leukemia

Ken ichi Ohtake, Tsutomu Takeuchi, Keiko Saito, Tatsuya Ito, Isao Ito, Kazutoshi Aoki, Yasuhide Takano, Koichi Amano, Osamu Hosono, Jim Koide, Tohru Abe, Hiroshi Suzuki

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5. (Internal Medicine 32: 565-568, 1993).

Original language	English
Pages (from-to)	565-568
Number of pages	4
Journal	Internal Medicine
Volume	32
Issue number	7
DOIs	https://doi.org/10.2169/internalmedicine.32.565
Publication status	Published - 1993
Externally published	Yes

Keywords

CD38
VLA-4
benign monoclonal gammopathy
multiple myeloma

ASJC Scopus subject areas

Internal Medicine

Access to Document

10.2169/internalmedicine.32.565

Cite this

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title = "Integrin VLA-5 negative primary plasma cell leukemia",

abstract = "We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5. (Internal Medicine 32: 565-568, 1993).",

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doi = "10.2169/internalmedicine.32.565",

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volume = "32",

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publisher = "Japanese Society of Internal Medicine",

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T1 - Integrin VLA-5 negative primary plasma cell leukemia

AU - Ohtake, Ken ichi

AU - Takeuchi, Tsutomu

AU - Saito, Keiko

AU - Ito, Tatsuya

AU - Ito, Isao

AU - Aoki, Kazutoshi

AU - Takano, Yasuhide

AU - Amano, Koichi

AU - Hosono, Osamu

AU - Koide, Jim

AU - Abe, Tohru

AU - Suzuki, Hiroshi

PY - 1993

Y1 - 1993

N2 - We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5. (Internal Medicine 32: 565-568, 1993).

AB - We present a case of primary plasma cell leukemia with Bence Jones proteinuria. After combination chemotherapy, leukemic cells and the urinary levels Bence Jones protein were decreased. Small lytic bone lesions were detected only in the skull. Typical plasma cells were rarely seen in peripheral blood on the hyperleukocytic phase, however they were increased in the advanced stages. The most important diagnostic sign was persistent expression of CD38 antigen on leukemic cells throughout the entire course of the illness and these leukemic cells expressed very late antigen-4 (VLA-4) but not VLA-5. (Internal Medicine 32: 565-568, 1993).

KW - CD38

KW - VLA-4

KW - benign monoclonal gammopathy

KW - multiple myeloma

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JO - Internal Medicine

JF - Internal Medicine

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Integrin VLA-5 negative primary plasma cell leukemia

Abstract

Keywords

ASJC Scopus subject areas

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