Interactions between temperature‐sensitive hydrogel microspheres and granulocytes

Koji Achiha, Rika Ojima, Yuji Kasuya, Keiji Fujimoto, Haruma Kawaguchi

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Poly(N‐isopropylacrylamide) (PNIPAM) has a low critical solution temperature (LCST) at 32°C in water and the hydrophilicity changes through the LCST. The microspheres whose surface was composed of PNIPAM exhibited phase transition behavior around 32°C. Therefore, the interactions between PNIPAM micropheres and granulocytes depended on the temperature. That is, the oxygen consumption and active oxygen production by cells in contact with PNIPAM‐containing microspheres and adhesion of the microspheres to the cell surface were more enhanced above the LCST of PNIPAM than below it, whereas no significant temperature dependence of cell–microspheres interaction was observed in nonthermosensitive microsphere systems. It was suggested that the function of cells could be controlled with temperature using the temperature‐sensitive microspheres.

Original languageEnglish
Pages (from-to)534-540
Number of pages7
JournalPolymers for Advanced Technologies
Issue number7
Publication statusPublished - 1995 Jul


  • cell activation
  • granulocyte
  • hydrogel
  • microsphere
  • poly(N‐isopropylacrylamide)

ASJC Scopus subject areas

  • Polymers and Plastics


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