Intertemporal Decision-Making Involves Prefrontal Control Mechanisms Associated with Working Memory

Koji Jimura, Maria S. Chushak, Andrew Westbrook, Todd S. Braver

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Intertemporal decision-making involves simultaneous evaluation of both the magnitude and delay to reward, which may require the integrated representation and comparison of these dimensions within working memory (WM). In the current study, neural activation associated with intertemporal decision-making was directly compared with WM load-related activation. During functional magnetic resonance imaging, participants performed an intermixed series of WM trials and intertemporal decision-making trials both varying in load, with the latter in terms of choice difficulty, via options tailored to each participant's subjective value function for delayed rewards. The right anterior prefrontal cortex (aPFC) and dorsolateral prefrontal cortex (dlPFC) showed activity modulation by choice difficulty within WM-related brain regions. In aPFC, these 2 effects (WM, choice difficulty) correlated across individuals. In dlPFC, activation increased with choice difficulty primarily in patient (self-controlled) individuals, and moreover was strongest when the delayed reward was chosen on the most difficult trials. Finally, the choice-difficulty effects in dlPFC and aPFC were correlated across individuals, suggesting a functional relationship between the 2 regions. Together, these results suggest a more precise account of the relationship between WM and intertemporal decision-making that is specifically tied to choice difficulty, and involves the coordinated activation of a lateral PFC circuit supporting successful self-control.

Original languageEnglish
Pages (from-to)1105-1116
Number of pages12
JournalCerebral cortex (New York, N.Y. : 1991)
Issue number4
Publication statusPublished - 2018 Apr 1

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience


Dive into the research topics of 'Intertemporal Decision-Making Involves Prefrontal Control Mechanisms Associated with Working Memory'. Together they form a unique fingerprint.

Cite this