TY - JOUR
T1 - Intracerebroventricular injection of brain natriuretic peptide inhibits vasopressin secretion in conscious rats
AU - Yamada, T.
AU - Nakao, K.
AU - Itoh, H.
AU - Shirakami, G.
AU - Kangawa, K.
AU - Minamino, N.
AU - Matsuo, H.
AU - Imura, H.
PY - 1988/12/19
Y1 - 1988/12/19
N2 - The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.
AB - The effect of intracerebroventricular (i.c.v.) injection of brain natriuretic peptide (BNP), a novel peptide purified from the porcine brain, on arginine vasopressin (AVP) secretion was studied in conscious, unrestrained rats and was compared with that of atrial natriuretic polypeptide (ANP). I.c.v. administration of BNP (0.01, 0.1 or 1 nmol) significantly inhibited basal AVP secretion and the effect of BNP was comparable to that of ANP. The AVP secretion induced by i.c.v. injection of angiotensin II (0.1 nmol) was significantly suppressed by the pretreatment with BNP (0.1 or 1 nmol). These results suggest that BNP is involved in the central control of AVP secretion either alone or in combination with brain ANP.
KW - Angiotensin II
KW - Arginine vasopressin
KW - Atrial natriuretic polypeptide
KW - Brain natriuretic peptide
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U2 - 10.1016/0304-3940(88)90661-1
DO - 10.1016/0304-3940(88)90661-1
M3 - Article
C2 - 3226610
AN - SCOPUS:0023815604
SN - 0304-3940
VL - 95
SP - 223
EP - 228
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-3
ER -