Intravascular large B-cell lymphoma involving large blood vessels, three autopsy cases

Shuku Sato, Shinichi Teshima, Naoya Nakamura, Takayasu Ohtake, Jun Kikuchi, Hirohisa Kishi, Kyoichi Nomura, Nozomu Kurose, Yasufumi Masaki, Jun ichi Tamaru

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Although intravascular large B-cell lymphoma (IVLBCL) is an extranodal lymphoma characterized by the selective growth of lymphoma cells within the lumina of small vessels, we here report three autopsy cases of IVLBCL characterized by the proliferation within large blood vessels. These three cases were diagnosed as IVLBCL of the bone marrow or skin biopsy. Two cases died suddenly before treatment, whereas the other died during treatment. Autopsies showed a large embolus of dense lymphoma cells extending from the truncus pulmonalis to the pulmonary arteries in Case 1, emboli of lymphoma cells in the aorta and carotis in Case 2, and a mass of lymphoma cells blocking the lumen of the aortic arch in Case 3. This is the first report of IVLBCL involving large blood vessels, and it is essential to note that this type of IVLBCL might cause sudden death because of tumor emboli within large blood vessels.

Original languageEnglish
Pages (from-to)97-103
Number of pages7
JournalPathology international
Issue number2
Publication statusPublished - 2019 Feb
Externally publishedYes


  • intravascular large B-cell lymphoma
  • large blood vessel
  • sudden death
  • tumor embolism

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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