Intravascular pancuronium bromide infusion for prenatal diagnosis of twin-twin transfusion syndrome

Mamoru Tanaka, Michiya Natori, Hitoshi Ishimoto, Hachiro Kohno, Toshifumi Kobayashi, Shiro Nozawa

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)


The diagnosis ot twin-twin transfusion syndrome remains a problem. Intravascular infusion of pancuronium bromide, a nondepolarizing neuromuscular blocking agent, for the smaller of a set of twins demonstrated paralysis of both twins in one case. However, in a second case, paralysis was shown only in the smaller twin who demonstrated no transplacental vascular communications postnatally. We suggest that infusion of pancuronium bromide, ‘pancuronium test’, is a simple and safe method for confirming transplacental communications and aids in the diagnosis of twin-twin transfusion syndrome.

Original languageEnglish
Pages (from-to)36-40
Number of pages5
JournalFetal Diagnosis and Therapy
Issue number1
Publication statusPublished - 1992 Jan 1


  • Fetal heart rate tracing
  • Intravascular infusion
  • Pancuronium bromide
  • Prenatal diagnosis
  • Syndrome
  • Twin-twin transfusion

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynaecology


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