Intravenous cyclophosphamide was effective in a case of recurrent optic disc vasculitis

Atsushi Tanaka, Wataru Saito, Chikako Yoshizawa, Kotaro Otomo, Takashi Kurita, Susumu Ishida

Research output: Contribution to journalArticlepeer-review


Purpose : To report a case of recurrent optic disc vasculitis that responded to intravenous cyclophosphamide. Case : A 35-year-old female present with impaired visual acuity in the right eye since one month before. She had been diagnosed with aplastic anemia at the age of 2 years and been receiving cyclosporine. Findings : Corrected visual acuity was 0.6 right and 1.2 left. The right eye showed swollen optic disc and was diagnosed with optic disc vasculitis. Spontaneous recovery set in after 2 weeks. Visual acuity in the left eye decreased to 0.07 3 months later. The left eye showed pale optic disc and was diagnosed with neuroretinitis and retinal vasculitis. Another 3 months later, the right eye showed recurrence of optic disc vasculitis. Visual acuity improved after systemic corticosteroid but declined after tapering or withdrawal. Intravenous cyclophosphamide was performed 14 times. Findings in both eyes stabilized with visual acuity of 1.0 right and 0.3 left 35 weeks after onset. Conclusion : The present case illustrates that systemic cyclophosphamide may be effective for optic disc vasculitis dependent on corticosteroid.

Original languageEnglish
Pages (from-to)707-712
Number of pages6
JournalJapanese Journal of Clinical Ophthalmology
Issue number5
Publication statusPublished - 2012 May 15
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology


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