Involvement of astrocytes in neurovascular communication

M. Nuriya, H. Hirase

Research output: Chapter in Book/Report/Conference proceedingConference contribution

27 Citations (Scopus)


The vascular interface of the brain is distinct from that of the peripheral tissue in that astrocytes, the most numerous glial cell type in the gray matter, cover the vasculature with their endfeet. This morphological feature of the gliovascular junction has prompted neuroscientists to suggest possible functional roles of astrocytes including astrocytic modulation of the vasculature. Additionally, astrocytes develop an intricate morphology that intimately apposes neuronal synapses, making them an ideal cellular mediator of neurovascular coupling. In this article, we first introduce the classical anatomical and physiological findings that led to the proposal of various gliovascular interaction models. Next, we touch on the technological advances in the past few decades that enabled investigations and evaluations of neuro-glio-vascular interactions in situ. We then review recent experimental findings on the roles of astrocytes in neurovascular coupling from the viewpoints of intra- and intercellular signalings in astrocytes.

Original languageEnglish
Title of host publicationNew Horizons in Neurovascular Coupling
Subtitle of host publicationA Bridge Between Brain Circulation and Neural Plasticity, 2016
EditorsKazuto Masamoto, Hajime Hirase, Katsuya Yamada
PublisherElsevier B.V.
Number of pages22
ISBN (Print)9780444637048
Publication statusPublished - 2016

Publication series

NameProgress in Brain Research
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855


  • AQP4
  • Astrocyte
  • Calcium
  • Endfeet
  • Gap junction
  • Neurovascular coupling
  • Potassium

ASJC Scopus subject areas

  • Neuroscience(all)


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