TY - JOUR
T1 - IRFs
T2 - Master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
AU - Honda, Kenya
AU - Taniguchi, Tadatsugu
N1 - Funding Information:
We thank E. Barsoumian, A. Takaoka, Y. Ohba and H. Yanai for valuable discussion and advice. This work was supported by Kakenhi (Grants-in-Aid for Scientific Research) on the Priority Area ‘Integrative Research Toward the Conquest of Cancer’, from the Ministry of Education, Culture, Sports, Science and Technology (Japan).
PY - 2006/9
Y1 - 2006/9
N2 - The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.
AB - The interferon-regulatory factor (IRF) family of transcription factors was initially found to be involved in the induction of genes that encode type I interferons. IRFs have now been shown to have functionally diverse roles in the regulation of the immune system. Recently, the crucial involvement of IRFs in innate and adaptive immune responses has been gaining much attention, particularly with the discovery of their role in immunoregulation by Toll-like receptors and other pattern-recognition receptors.
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U2 - 10.1038/nri1900
DO - 10.1038/nri1900
M3 - Review article
C2 - 16932750
AN - SCOPUS:33748051738
SN - 1474-1733
VL - 6
SP - 644
EP - 658
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 9
ER -