Iridium-catalyzed chemoselective reductive nucleophilic addition to n -methoxyamides

Minami Nakajima, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)


Iridium-catalyzed reductive nucleophilic addition to N-methoxyamides is reported. The reaction took place in high yields in the presence of a variety of sensitive functional groups such as esters and nitro groups. Mechanistic studies revealed that the reaction of N-methoxyamides proceeded without equilibrium to an enamine intermediate in contrast to that with tert-amides.

Original languageEnglish
Pages (from-to)1696-1699
Number of pages4
JournalOrganic Letters
Issue number7
Publication statusPublished - 2015 Apr 3

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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