Iridium-catalyzed reductive nucleophilic addition to tertiary amides

Yoshito Takahashi, Takaaki Sato, Noritaka Chida

Research output: Contribution to journalReview articlepeer-review

36 Citations (Scopus)


This article describes the development of an iridium-catalyzed reductive nucleophilic addition to tertiary amides. A conspicuous feature of this reaction is its high amide-selectivity via two processes: i) chemoselective hydrosilylation of amide carbonyls with Vaska’s complex [IrCl(CO)(PPh3)2] and (Me2HSi)2O, and ii) subsequent addition of a variety of mild nucleophiles to the resulting electrophilic iminium ions by the assistance of an acid. The reaction takes place in the presence of a variety of functional groups such as ester and nitro groups.

Original languageEnglish
Pages (from-to)1138-1141
Number of pages4
JournalChemistry Letters
Issue number9
Publication statusPublished - 2019


  • Amides
  • Iridium catalyst
  • Nucleophilic addition

ASJC Scopus subject areas

  • General Chemistry


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