TY - JOUR
T1 - Iron-Catalyzed Regio- and Stereoselective C-H Alkenylation of Pivalophenone Derivatives with Unsymmetric Internal Alkynes
AU - Kitazawa, Yoichi
AU - Kochi, Takuya
AU - Kakiuchi, Fumitoshi
N1 - Funding Information:
This work was supported in part by JST CREST Grant JPMJCR20R1. Y.K. is also supported by JST SPRING, Grant JPMJSP2123, and the Keio University Doctorate Student Grant-in-Aid Program from Ushioda Memorial Fund.
Publisher Copyright:
© 2023 American Chemical Society.
PY - 2023/2/3
Y1 - 2023/2/3
N2 - Here we report an ortho-C-H alkenylation of aromatic ketones with unsymmetric internal alkynes catalyzed by an iron phosphine complex, Fe(PMe3)4. The use of a catalytic amount of PtBu3 as an additive was found to improve the product yields. The alkenylation proceeds regio- and stereoselectively to give the corresponding styrene derivatives.
AB - Here we report an ortho-C-H alkenylation of aromatic ketones with unsymmetric internal alkynes catalyzed by an iron phosphine complex, Fe(PMe3)4. The use of a catalytic amount of PtBu3 as an additive was found to improve the product yields. The alkenylation proceeds regio- and stereoselectively to give the corresponding styrene derivatives.
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U2 - 10.1021/acs.joc.2c02608
DO - 10.1021/acs.joc.2c02608
M3 - Article
AN - SCOPUS:85146385376
SN - 0022-3263
VL - 88
SP - 1890
EP - 1897
JO - Journal of Organic Chemistry
JF - Journal of Organic Chemistry
IS - 3
ER -