Irreversible aggregation of alternating tetra-block-like amphiphile in water

Shota Konno, Taisuke Banno, Hideaki Takagi, Satoshi Honda, Taro Toyota

Research output: Contribution to journalArticlepeer-review


As a frontier topic of soft condensed matter physics, irreversible aggregation has drawn attention for a better understanding of the complex behavior of biomaterials. In this study, we have described the synthesis of an artificial amphiphilic molecule, an alternating tetra-block-like amphiphile, which was able to diversify its aggregate structure in water. The aggregated state of its aqueous dispersion was obtained by slow evaporation of the organic solvent at room temperature, and it collapsed irreversibly at ~ 50C. By using a cryo-trans-mission electron microscope and a differential scanning calorimeter, it was revealed that two types of molecular nanostructures were formed and developed into submicro- and micrometer-sized fibrils in the aggregated material.

Original languageEnglish
Article numbere0202816
JournalPloS one
Issue number8
Publication statusPublished - 2018 Aug

ASJC Scopus subject areas

  • General


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