TY - JOUR
T1 - Irreversible aggregation of alternating tetra-block-like amphiphile in water
AU - Konno, Shota
AU - Banno, Taisuke
AU - Takagi, Hideaki
AU - Honda, Satoshi
AU - Toyota, Taro
N1 - Funding Information:
This work was partially supported by KAKENHI of Japan Society for the Promotion of Science (Grant Numbers 16K14074 S.H. and 16H04032 T.T.) [see https://www.jsps.go.jp/]and the Izumi Science and Technology Foundation (S. H.) [seehttp://www.izumi-zaidan.jp/]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. This work benefited from fruitful discussions with Prof. Hideki Seto (High Energy Accelerator Research Organization, KEK, Japan), Dr. Taku Ogura (Lion Corp., Japan) and Prof. Atsushi Ikeda (The University of Tokyo, Japan). Synchrotron radiation-SAXS measurements were performed under the approval of the Photon Factory Program Advisory Committee (Proposal No. 2016PF-02 H.T.). Cryo-TEM measurements were conducted under the approval of the Advanced Characterization Nanotechnology Platform of the University of Tokyo, supported by the "Nanotechnology Platform" of the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan (Proposal No. A-16-UT-0225 S.H.). The authors acknowledge Ms. Misuzu Konishi and Mr. Hiroshi Ohki (Mettler-Toledo Japan) for support with DSC measurements and Dr. Shunji Yunoki and Mr. Hirosuke Hatayama (Tokyo Metropolitan Industrial Technology Research Institute) for support with DMA. This work was partially supported by KAKENHI of Japan Society for the Promotion of Science (Grant Numbers 16K14074 S.H. and 16H04032 T.T.) and the Izumi Science and Technology Foundation (S.H.).
Publisher Copyright:
© 2018 Konno et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2018/8
Y1 - 2018/8
N2 - As a frontier topic of soft condensed matter physics, irreversible aggregation has drawn attention for a better understanding of the complex behavior of biomaterials. In this study, we have described the synthesis of an artificial amphiphilic molecule, an alternating tetra-block-like amphiphile, which was able to diversify its aggregate structure in water. The aggregated state of its aqueous dispersion was obtained by slow evaporation of the organic solvent at room temperature, and it collapsed irreversibly at ~ 50C. By using a cryo-trans-mission electron microscope and a differential scanning calorimeter, it was revealed that two types of molecular nanostructures were formed and developed into submicro- and micrometer-sized fibrils in the aggregated material.
AB - As a frontier topic of soft condensed matter physics, irreversible aggregation has drawn attention for a better understanding of the complex behavior of biomaterials. In this study, we have described the synthesis of an artificial amphiphilic molecule, an alternating tetra-block-like amphiphile, which was able to diversify its aggregate structure in water. The aggregated state of its aqueous dispersion was obtained by slow evaporation of the organic solvent at room temperature, and it collapsed irreversibly at ~ 50C. By using a cryo-trans-mission electron microscope and a differential scanning calorimeter, it was revealed that two types of molecular nanostructures were formed and developed into submicro- and micrometer-sized fibrils in the aggregated material.
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U2 - 10.1371/journal.pone.0202816
DO - 10.1371/journal.pone.0202816
M3 - Article
C2 - 30148887
AN - SCOPUS:85052653954
SN - 1932-6203
VL - 13
JO - PloS one
JF - PloS one
IS - 8
M1 - e0202816
ER -