Is central dogma a global property of cellular information flow?

Vincent Piras, Masaru Tomita, Kumar Selvarajoo

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


The central dogma of molecular biology has come under scrutiny in recent years. Here, we reviewed high-throughput mRNA and protein expression data of Escherichia coli, Saccharomyces cerevisiae, and several mammalian cells. At both single cell and population scales, the statistical comparisons between the entire transcriptomes and proteomes show clear correlation structures. In contrast, the pair-wise correlations of single transcripts to proteins show nullity. These data suggest that the organizing structure guiding cellular processes is observed at omics-wide scale, and not at single molecule level. The central dogma, thus, globally emerges as an average integrated flow of cellular information.

Original languageEnglish
Article numberArticle 439
JournalFrontiers in Physiology
Volume3 NOV
Publication statusPublished - 2012


  • Biological noise
  • Central dogma
  • Correlation analysis
  • Emergent behavior
  • Gene expression

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)


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