TY - JOUR
T1 - Isoflavone intake and risk of gastric cancer
T2 - A population-based prospective cohort study in Japan
AU - Hara, Azusa
AU - Sasazuki, Shizuka
AU - Inoue, Manami
AU - Iwasaki, Motoki
AU - Shimazu, Taichi
AU - Sawada, Norie
AU - Yamaji, Taiki
AU - Tsugane, Shoichiro
PY - 2012/1/1
Y1 - 2012/1/1
N2 - Background: Isoflavones are structurally similar to 17β-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed. Objective: We investigated the association between isoflavone intake and the incidence of gastric cancer. Design: We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45-74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998. Results: During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04). Conclusion: The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women.
AB - Background: Isoflavones are structurally similar to 17β-estradiol and may be able to prevent gastric cancer. However, there is contradictory evidence concerning the relation between the intake of soy food, which is rich in isoflavones, and gastric cancer. The association with gastric cancer might differ between isoflavones and soy foods, and research on the effects of isoflavone intake alone on gastric cancer is needed. Objective: We investigated the association between isoflavone intake and the incidence of gastric cancer. Design: We conducted a large, population-based prospective study of 39,569 men and 45,312 women aged 45-74 y. Dietary soy and isoflavone intakes were measured by using a validated food-frequency questionnaire in 1995 and 1998. Results: During 806,550 person-years of follow-up, we identified 1249 new gastric cancer cases. Isoflavone intake was not associated with gastric cancer in either men or women. Compared with the lowest quartile, the HR and 95% CI for developing gastric cancer in the fourth quartile of isoflavone intake was 1.00 (0.81, 1.24) for men and 1.07 (0.77, 1.50) for women. In a stratified analysis by exogenous female hormones (women only), however, we found an increasing trend in risk of gastric cancer associated with higher isoflavone intakes among exogenous female hormone users (P-trend = 0.03) but not for nonusers (P-interaction = 0.04). Conclusion: The current study does not support the hypothesis that higher intakes of isoflavones prevent gastric cancer in either men or women.
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U2 - 10.3945/ajcn.111.020479
DO - 10.3945/ajcn.111.020479
M3 - Article
C2 - 22170362
AN - SCOPUS:84455160876
SN - 0002-9165
VL - 95
SP - 147
EP - 154
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
IS - 1
ER -
