Isolated lung transplantation for patients with Eisenmenger's syndrome

Ryo Aeba, Bartley P. Griffith, Robert L. Hardesty, Robert L. Kormos, John M. Armitage

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Background. Eisenmenger's syndrome remains one of the greatest challenges in lung transplantation. Methods and Results. Since October 1990, seven such patients with Eisenmenger's syndrome received isolated pulmonary grafts (six double lungs and one single lung). Mean patient age was 32±6 years (two men and five women). The preoperative mean pulmonary arterial pressure was 90.7±31.2 mm Hg, and the ventriculoscintigram showed markedly enlarged right ventricle and normal left ventricular function with ejection fraction of 0.660±0.115. Three atrial septal defects and four patent ducti arteriosus were repaired concomitantly. Excised lung histology showed plexogenic pulmonary arteriopathy with Heath-Edwards' grade 4 through 6. One double lung patient who had preexisting systemic vascular collapse died intraoperatively. The other six patients tolerated transplantation, and on the first operative day, mean pulmonary artery pressure decreased to 22.4±7.3 mm Hg (P<.002) and gas exchange was acceptable with an arterial/alveolar oxygen tension ratio of 0.47±0.15. Two patients died of mediastinal and pulmonary infection. The follow-up for the four survivors ranged from 13 to 25 months after transplantation. Conclusions. Our preliminary experience shows that concomitant isolated lung transplantation with cardiac repair could be a viable therapeutic option for patients with Eisenmenger's syndrome and normal left ventricular function. Dynamic right ventricular outflow obstruction is a potential hemodynamic problem in these pulmonary recipients.

Original languageEnglish
Pages (from-to)452-455
Number of pages4
Issue number5 PART 2
Publication statusPublished - 1993 Nov
Externally publishedYes


  • Eisenmenger's syndrome
  • Hypertension
  • Lungs
  • Transplant

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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