Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Shinichiro Okamoto; Arihiro Iwasaki; Osamu Ohno; Kiyotake Suenaga

doi:10.1021/acs.jnatprod.5b00662

Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Shinichiro Okamoto, Arihiro Iwasaki, Osamu Ohno, Kiyotake Suenaga

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC₅₀ values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.

Original language	English
Pages (from-to)	2719-2725
Number of pages	7
Journal	Journal of Natural Products
Volume	78
Issue number	11
DOIs	https://doi.org/10.1021/acs.jnatprod.5b00662
Publication status	Published - 2015 Nov 25

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.5b00662

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abstract = "Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.",

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AU - Ohno, Osamu

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AB - Kurahyne B (2), a new analogue of kurahyne (1), was isolated from the marine cyanobacterium Okeania sp. Its gross structure was elucidated based on spectroscopic analyses, and the absolute configuration was established by total synthesis. Kurahyne B (2) inhibited the growth of both HeLa and HL60 cells, with IC50 values of 8.1 and 9.0 μM, respectively. The growth-inhibitory activity of kurahyne B was the same as kurahyne (1). In parallel, the first total synthesis of kurahyne (1) was also achieved.

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Isolation and Structure of Kurahyne B and Total Synthesis of the Kurahynes

Abstract

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