@article{a57799576b31475ebeecca4a8ba339b4,
title = "Isolation and structures of biselyngbyasides B, C, and D from the marine cyanobacterium Lyngbya sp., and the biological activities of biselyngbyasides",
abstract = "Bioassay-guided fractionation of the marine cyanobacterium Lyngbya sp. led to the isolation of biselyngbyasides B (3), C (4), and D (5), novel analogs of biselyngbyaside (1) and biselyngbyolide A (2). The gross structures of 3-5 were determined by NMR spectral analyses, and their stereochemistries were established based on NOESY spectra and CD data. Biselyngbyasides (1-3) showed growth-inhibitory activity and apoptosis-inducing activity against both HeLa S 3 cells and HL60 cells. The fura-2 method revealed that biselyngbyasides (1-3) increased the cytosolic Ca 2+ concentration in HeLa S 3 cells.",
keywords = "Apoptosis, Biselyngbyaside, Calcium, Cyanobacteria, Marine natural products",
author = "Maho Morita and Osamu Ohno and Toshiaki Teruya and Takao Yamori and Toshiyasu Inuzuka and Kiyotake Suenaga",
note = "Funding Information: We sincerely thank Prof. Shoichiro Suda (University of Ryukyus) for identifying the cyanobacterium. We are also deeply grateful to Prof. Kazuo Umezawa (Keio University) for providing HL60 cells. We would like to thank Assoc. Prof. Kenji Miyamoto (Keio University) for the use of a UV transilluminator. We thank Prof. Keiji Fujimoto (Keio University) for allowing us to use a CD spectrometer. We are grateful to Dr. Chisato Kurosaki for advice on the measurement of high-resolution NMR spectra. This work was supported in part by Keio Gijuku Academic Development Funds and a Grant for Private Education Institute Aid from the Ministry of Education, Culture, Sports, Science and Technology , Japan. ",
year = "2012",
month = jul,
day = "29",
doi = "10.1016/j.tet.2012.05.038",
language = "English",
volume = "68",
pages = "5984--5990",
journal = "Tetrahedron",
issn = "0040-4020",
publisher = "Elsevier Limited",
number = "30",
}
