Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

N. Takada; M. Watanabe; A. Yamada; K. Suenaga; K. Yamada; K. Ueda; D. Uemura

doi:10.1021/np0003490

Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

N. Takada, M. Watanabe, A. Yamada, K. Suenaga, K. Yamada, K. Ueda, D. Uemura

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

Original language	English
Pages (from-to)	356-359
Number of pages	4
Journal	Journal of Natural Products
Volume	64
Issue number	3
DOIs	https://doi.org/10.1021/np0003490
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np0003490

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AU - Suenaga, K.

AU - Yamada, K.

AU - Ueda, K.

AU - Uemura, D.

PY - 2001

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AB - Cytotoxic endoperoxides, haterumadioxins A (1) and B (2), were isolated from the Okinawan sponge Plakortis lita. Their structures were determined by spectroscopic analysis. The absolute stereostructure of 1 was determined by degradation reactions and the modified Mosher's method. Haterumadioxins showed significant cytotoxicity against 38 human cancer cell lines.

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Isolation and structures of haterumadioxins A and B, cytotoxic endoperoxides from the Okinawan sponge Plakortis lita

Abstract

ASJC Scopus subject areas

UN SDGs

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