Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki; Mariko Ikeda; Kenji Miyamoto; Osamu Ohno; Kaoru Yamada; Daisuke Uemura

doi:10.1271/bbb.110994

Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Keiji Yuki, Mariko Ikeda, Kenji Miyamoto, Osamu Ohno, Kaoru Yamada, Daisuke Uemura

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

Original language	English
Pages (from-to)	1233-1235
Number of pages	3
Journal	Bioscience, Biotechnology and Biochemistry
Volume	76
Issue number	6
DOIs	https://doi.org/10.1271/bbb.110994
Publication status	Published - 2012

Keywords

3T3-L1 murine adipocytes
Fat accumulation
Inhibitor
Valeriana fauriei

ASJC Scopus subject areas

Biotechnology
Analytical Chemistry
Biochemistry
Applied Microbiology and Biotechnology
Molecular Biology
Organic Chemistry

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10.1271/bbb.110994

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abstract = "An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.",

keywords = "3T3-L1 murine adipocytes, Fat accumulation, Inhibitor, Valeriana fauriei",

author = "Keiji Yuki and Mariko Ikeda and Kenji Miyamoto and Osamu Ohno and Kaoru Yamada and Daisuke Uemura",

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AU - Yuki, Keiji

AU - Ikeda, Mariko

AU - Miyamoto, Kenji

AU - Ohno, Osamu

AU - Yamada, Kaoru

AU - Uemura, Daisuke

PY - 2012

Y1 - 2012

N2 - An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

AB - An EtOH extract of Valeriana fauriei was found to exhibit potent inhibition of fat accumulation against 3T3-L1 murine adipocytes. After performing several chromatographic steps, we successfully isolated the conjugated linoleic acid derivative, 9-hydroxy-10E,12Z-octadecadienoic acid (9-HODE). Synthesized 9-HODE and its analogs showed inhibitory activity against fat accumulation.

KW - 3T3-L1 murine adipocytes

KW - Fat accumulation

KW - Inhibitor

KW - Valeriana fauriei

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JO - Bioscience, Biotechnology and Biochemistry

JF - Bioscience, Biotechnology and Biochemistry

IS - 6

ER -

Isolation of 9-hydroxy-10E,12Z-octadecadienoic acid, an inhibitor of fat accumulation from Valeriana fauriei

Abstract

Keywords

ASJC Scopus subject areas

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