Isolation of a Drosophila Gene Encoding a Head‐Specific Guanylyl Cyclase

Shingo Yoshikawa, Issei Miyamoto, Jun Aruga, Teiichi Furuichi, Hideyuki Okano, Katsuhiko Mikoshiba

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23 Citations (Scopus)


Abstract: We have isolated and characterized a new guanylyl cyclase gene (dgcl) in Drosophila. The deduced amino acid sequence (683 amino acids) most closely resembled the mammalian solubletype guanylyl cyclase α subunit. The cyclase catalytic domain was highly conserved between the mammalian and Drosophila guanylyl cyclases. The dgcl mRNA was detected in wild‐type heads but not in bodies, and its level was reduced in the mutant eyes absent (eya), indicating that dgcl is preferentially expressed in the CNS and in the eye. The enriched distribution in the eye suggests that dgcl may have a role in phototransduction.

Original languageEnglish
Pages (from-to)1570-1573
Number of pages4
JournalJournal of Neurochemistry
Issue number4
Publication statusPublished - 1993 Apr
Externally publishedYes


  • CNS
  • Drosophila dgcl gene
  • Guanylyl cyclase
  • Phototransduction

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience


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