Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi; Palupi Margiastuti; Toshiaki Teruya; Junsei Taira; Kiyotake Suenaga; Katsuhiro Ueda

doi:10.3390/md7040816

Isolation of C₁₁ cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

Takayuki Ogi
, Palupi Margiastuti
, Toshiaki Teruya
, Junsei Taira
, Kiyotake Suenaga
, Katsuhiro Ueda

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

23 Citations (Scopus)

Abstract

A series of new C₁₁ cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

Original language	English
Pages (from-to)	816-832
Number of pages	17
Journal	Marine Drugs
Volume	7
Issue number	4
DOIs	https://doi.org/10.3390/md7040816
Publication status	Published - 2009 Dec

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cyclopentenone
Cytotoxicity
Didemnenone
Diplosoma
Lissoclinum

ASJC Scopus subject areas

Drug Discovery

Access to Document

10.3390/md7040816

Cite this

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title = "Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.",

abstract = "A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).",

keywords = "Cyclopentenone, Cytotoxicity, Didemnenone, Diplosoma, Lissoclinum",

author = "Takayuki Ogi and Palupi Margiastuti and Toshiaki Teruya and Junsei Taira and Kiyotake Suenaga and Katsuhiro Ueda",

year = "2009",

month = dec,

doi = "10.3390/md7040816",

language = "English",

volume = "7",

pages = "816--832",

journal = "Marine Drugs",

issn = "1660-3397",

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T1 - Isolation of C11 cyclopentenones from two didemnid species, Lissoclinum sp. and Diplosoma sp.

AU - Ogi, Takayuki

AU - Margiastuti, Palupi

AU - Teruya, Toshiaki

AU - Taira, Junsei

AU - Suenaga, Kiyotake

AU - Ueda, Katsuhiro

PY - 2009/12

Y1 - 2009/12

N2 - A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

AB - A series of new C11 cyclopentenones 1-7 was isolated, together with four known metabolites 9/10, 12 and 13, from the extract of the didemnid ascidian Lissoclinum sp. The other didemnid ascidian Diplosoma sp. contained didemnenones 1, 2 and 5, and five known metabolites 8-12. The structures of 1-7 were elucidated by spectroscopic analyses. Cytotoxicity of the isolated compounds was evaluated against three human cancer cell lines (HCT116, A431 and A549).

KW - Cyclopentenone

KW - Cytotoxicity

KW - Didemnenone

KW - Diplosoma

KW - Lissoclinum

UR - https://www.scopus.com/pages/publications/75149198747

UR - https://www.scopus.com/pages/publications/75149198747#tab=citedBy

U2 - 10.3390/md7040816

DO - 10.3390/md7040816

M3 - Article

C2 - 20098612

AN - SCOPUS:75149198747

SN - 1660-3397

VL - 7

SP - 816

EP - 832

JO - Marine Drugs

JF - Marine Drugs

IS - 4

ER -