Japanese guidelines for the management of palmoplantar keratoderma

Committee on Guidelines for the Management of PPKs

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4 Citations (Scopus)


Palmoplantar keratoderma (PPK) is a collective term for keratinizing disorders in which the main clinical symptom is hyperkeratosis on the palms and soles. To establish the first Japanese guidelines approved by the Japanese Dermatological Association for the management of PPKs, the Committee for the Management of PPKs was founded as part of the Study Group for Rare Intractable Diseases. These guidelines aim to provide current information for the management of PPKs in Japan. Based on evidence, they summarize the clinical manifestations, pathophysiologies, diagnostic criteria, disease severity determination criteria, treatment, and treatment recommendations. Because of the rarity of PPKs, there are only few clinical studies with a high degree of evidence. Therefore, several parts of these guidelines were established based on the opinions of the committee. To further optimize the guidelines, periodic revision in line with new evidence is necessary.

Original languageEnglish
Pages (from-to)e353-e367
JournalJournal of Dermatology
Issue number8
Publication statusPublished - 2021 Aug


  • diagnostic algorithm
  • palmoplantar keratoderma
  • treatment

ASJC Scopus subject areas

  • Dermatology


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