Japanese studies on neural circuits and behavior of Caenorhabditis elegans

Hiroyuki Sasakura, Yuki Tsukada, Shin Takagi, Ikue Mori

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)

Abstract

The nematode Caenorhabditis elegans is an ideal organism for studying neural plasticity and animal behaviors. A total of 302 neurons of a C. elegans hermaphrodite have been classified into 118 neuronal groups. This simple neural circuit provides a solid basis for understanding the mechanisms of the brains of higher animals, including humans. Recent studies that employ modern imaging and manipulation techniques enable researchers to study the dynamic properties of nervous systems with great precision. Behavioral and molecular genetic analyses of this tiny animal have contributed greatly to the advancement of neural circuit research. Here, we will review the recent studies on the neural circuits of C. elegans that have been conducted in Japan. Several laboratories have established unique and clever methods to study the underlying neuronal substrates of behavioral regulation in C. elegans. The technological advances applied to studies of C. elegans have allowed new approaches for the studies of complex neural systems. Through reviewing the studies on the neuronal circuits of C. elegans in Japan, we will analyze and discuss the directions of neural circuit studies.

Original languageEnglish
Pages (from-to)187
Number of pages1
JournalFrontiers in Neural Circuits
Volume7
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • C. elegans
  • behavioral genetics
  • learning and memory
  • neural circuits
  • plastic behavior
  • studies on Japan

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Sensory Systems
  • Cognitive Neuroscience
  • Cellular and Molecular Neuroscience

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