Kampo extract of shinbuto improved refractory diarrhea in milroy's disease

Yuko Horiba, Tetsuhiro Yoshino, Kenji Watanabe

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Milroy's disease is a hereditary congenital lymphedema caused by lymphatic obstruction. The legs are most commonly affected, but impaired intestinal lymphatic flow can cause loose bowel movements. Here, we report the use of the Kampo extract of shinbuto for successful treatment of and abdominal pain in a patient with Milroy's disease. Milroy's disease was diagnosed because of left leg lymphedema with onset at birth. Conservative therapy with a compression bandage was applied. However, when the patient moved to Manila at 35 years of age, she was exposed to drastic temperature changes between the air-conditioned cold environment in her room and the hot and humid environment outside. She developed a constitutional state of coldness as in hiesho Then sudden lower abdominal pain and diarrhea began to occur 3 times per week and lasted at least 1 hour, sometimes accompanied by vomiting. It happened particularly when she was exposed to the cold environment and was not related to meals. Conventional anti-cholinergic or antidiarrhetic drugs had no therapeutic effect. These attacks continued in the same frequency for 3 years, so the patient visited a Kampo (traditional Japanese medicine) clinic, where her diagnosis of Milroy's disease-associated diarrhea and abdominal pain was augmented by the Kampo diagnosis of hiesho, suitai (body fluid retention). She was prescribed 7.5 g of shinbuto extract per day (TJ-30; Tsumura Co, Tokyo, Japan). The shinbuto extract significantly reduced abdominal pain and refractory diarrhea to about 2 days.

Original languageEnglish
Pages (from-to)14-17
Number of pages4
JournalGlobal Advances In Health and Medicine
Issue number1
Publication statusPublished - 2013 Jan


  • Body fluid retention (suitai)
  • Coldness (hie)
  • Diarrhea
  • Kampo medicine
  • Lymphedema
  • Milroy's disease

ASJC Scopus subject areas

  • Medicine(all)


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