TY - JOUR
T1 - Keio Uterus Transplantation Research
T2 - From Basic Research toward Future Clinical Application
AU - Kisu, Iori
AU - Banno, Kouji
AU - Matoba, Yusuke
AU - Yamada, Yohei
AU - Emoto, Katsura
AU - Masugi, Yohei
AU - Matsubara, Kentaro
AU - Obara, Hideaki
AU - Aoki, Daisuke
N1 - Publisher Copyright:
© 2022, Keio University School of Medicine. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Uterus transplantation (UTx) is now a potential option to allow women with uterine factor infertility to give birth. However, UTx is still at an experimental stage, and basic animal studies, including in nonhuman primates, are needed for the accumulation of data prior to clinical application. Considering that UTx may provide new hope to Japanese women, we launched UTx research in 2009 and have since accumulated a large archive of results in the UTx research field. Furthermore, we have carried out various activities aimed at the implementation of clinical applications of UTx in Japan while clarifying the ethical and social issues involved. Currently, the clinical application of UTx in Japan is just around the corner, and it is expected that UTx research will develop further in the future. Herein, we summarize our basic experiences using non-human primates and our activities with the goal of future clinical applications.
AB - Uterus transplantation (UTx) is now a potential option to allow women with uterine factor infertility to give birth. However, UTx is still at an experimental stage, and basic animal studies, including in nonhuman primates, are needed for the accumulation of data prior to clinical application. Considering that UTx may provide new hope to Japanese women, we launched UTx research in 2009 and have since accumulated a large archive of results in the UTx research field. Furthermore, we have carried out various activities aimed at the implementation of clinical applications of UTx in Japan while clarifying the ethical and social issues involved. Currently, the clinical application of UTx in Japan is just around the corner, and it is expected that UTx research will develop further in the future. Herein, we summarize our basic experiences using non-human primates and our activities with the goal of future clinical applications.
KW - cynomolgus macaque
KW - non-human primate
KW - surrogacy
KW - uterine factor infertility
KW - uterus transplantation
UR - http://www.scopus.com/inward/record.url?scp=85133103366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85133103366&partnerID=8YFLogxK
U2 - 10.2302/kjm.2021-0008-IR
DO - 10.2302/kjm.2021-0008-IR
M3 - Article
C2 - 35046207
AN - SCOPUS:85133103366
SN - 0022-9717
VL - 71
SP - 33
EP - 43
JO - Keio Journal of Medicine
JF - Keio Journal of Medicine
IS - 2
ER -
