Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata

Kaori Ozaki; Atsuhide Jinno; Noriyuki Natsume; Shimpei Sumimoto; Arihiro Iwasaki; Kiyotake Suenaga; Toshiaki Teruya

doi:10.1016/j.tet.2021.131969

Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata

Kaori Ozaki, Atsuhide Jinno, Noriyuki Natsume, Shimpei Sumimoto, Arihiro Iwasaki, Kiyotake Suenaga, Toshiaki Teruya

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The linear lipopeptides komesuamide (1) and odopenicillatamide (2) were isolated from Caldora penicillata a marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were determined by HPLC analyses of the acid hydrolysates. Both compounds showed glucose uptake activity at 40 μM in cultured L6 myotubes.

Original language	English
Article number	131969
Journal	Tetrahedron
Volume	85
DOIs	https://doi.org/10.1016/j.tet.2021.131969
Publication status	Published - 2021 Apr 9

Keywords

Caldora penicillata
Glucose uptake activity
Linear lipopeptide
Marine cyanobacteria

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2021.131969

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title = "Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata",

abstract = "The linear lipopeptides komesuamide (1) and odopenicillatamide (2) were isolated from Caldora penicillata a marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were determined by HPLC analyses of the acid hydrolysates. Both compounds showed glucose uptake activity at 40 μM in cultured L6 myotubes.",

keywords = "Caldora penicillata, Glucose uptake activity, Linear lipopeptide, Marine cyanobacteria",

author = "Kaori Ozaki and Atsuhide Jinno and Noriyuki Natsume and Shimpei Sumimoto and Arihiro Iwasaki and Kiyotake Suenaga and Toshiaki Teruya",

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doi = "10.1016/j.tet.2021.131969",

language = "English",

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T1 - Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata

AU - Ozaki, Kaori

AU - Jinno, Atsuhide

AU - Natsume, Noriyuki

AU - Sumimoto, Shimpei

AU - Iwasaki, Arihiro

AU - Suenaga, Kiyotake

AU - Teruya, Toshiaki

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for 15K01803 and 18K05337 from the Ministry of Education, Culture, Sports, Science and Technology , Japan. Publisher Copyright: © 2021 Elsevier Ltd

PY - 2021/4/9

Y1 - 2021/4/9

N2 - The linear lipopeptides komesuamide (1) and odopenicillatamide (2) were isolated from Caldora penicillata a marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were determined by HPLC analyses of the acid hydrolysates. Both compounds showed glucose uptake activity at 40 μM in cultured L6 myotubes.

AB - The linear lipopeptides komesuamide (1) and odopenicillatamide (2) were isolated from Caldora penicillata a marine cyanobacterium collected in Okinawa. The structures of these compounds were established by spectroscopic analyses, and the absolute configurations were determined by HPLC analyses of the acid hydrolysates. Both compounds showed glucose uptake activity at 40 μM in cultured L6 myotubes.

KW - Caldora penicillata

KW - Glucose uptake activity

KW - Linear lipopeptide

KW - Marine cyanobacteria

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DO - 10.1016/j.tet.2021.131969

M3 - Article

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SN - 0040-4020

VL - 85

JO - Tetrahedron

JF - Tetrahedron

M1 - 131969

ER -

Komesuamide and odopenicillatamide, two linear lipopeptides from the marine cyanobacterium Caldora penicillata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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