Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Yohei Takahashi; Morio Matsumoto; Tatsuki Karasugi; Kota Watanabe; Kazuhiro Chiba; Noriaki Kawakami; Taichi Tsuji; Koki Uno; Teppei Suzuki; Manabu Ito; Hideki Sudo; Shohei Minami; Toshiaki Kotani; Katsuki Kono; Haruhisa Yanagida; Hiroshi Taneichi; Atsushi Takahashi; Yoshiaki Toyama; Shiro Ikegawa

doi:10.1002/jor.21347

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Yohei Takahashi, Morio Matsumoto, Tatsuki Karasugi, Kota Watanabe, Kazuhiro Chiba, Noriaki Kawakami, Taichi Tsuji, Koki Uno, Teppei Suzuki, Manabu Ito, Hideki Sudo, Shohei Minami, Toshiaki Kotani, Katsuki Kono, Haruhisa Yanagida, Hiroshi Taneichi, Atsushi Takahashi, Yoshiaki Toyama, Shiro Ikegawa

Department of Orthopaedics

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Abstract

Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

Original language	English
Pages (from-to)	1055-1058
Number of pages	4
Journal	Journal of Orthopaedic Research
Volume	29
Issue number	7
DOIs	https://doi.org/10.1002/jor.21347
Publication status	Published - 2011 Jul

Keywords

adolescent idiopathic scoliosis
association
curve severity
predisposition

ASJC Scopus subject areas

Orthopedics and Sports Medicine

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10.1002/jor.21347

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Takahashi, Y., Matsumoto, M., Karasugi, T., Watanabe, K., Chiba, K., Kawakami, N., Tsuji, T., Uno, K., Suzuki, T., Ito, M., Sudo, H., Minami, S., Kotani, T., Kono, K., Yanagida, H., Taneichi, H., Takahashi, A., Toyama, Y., & Ikegawa, S. (2011). Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. Journal of Orthopaedic Research, 29(7), 1055-1058. https://doi.org/10.1002/jor.21347

Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population. / Takahashi, Yohei; Matsumoto, Morio; Karasugi, Tatsuki et al.
In: Journal of Orthopaedic Research, Vol. 29, No. 7, 07.2011, p. 1055-1058.

Research output: Contribution to journal › Article › peer-review

Takahashi, Y, Matsumoto, M, Karasugi, T, Watanabe, K, Chiba, K, Kawakami, N, Tsuji, T, Uno, K, Suzuki, T, Ito, M, Sudo, H, Minami, S, Kotani, T, Kono, K, Yanagida, H, Taneichi, H, Takahashi, A, Toyama, Y & Ikegawa, S 2011, 'Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population', Journal of Orthopaedic Research, vol. 29, no. 7, pp. 1055-1058. https://doi.org/10.1002/jor.21347

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title = "Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population",

abstract = "Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.",

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author = "Yohei Takahashi and Morio Matsumoto and Tatsuki Karasugi and Kota Watanabe and Kazuhiro Chiba and Noriaki Kawakami and Taichi Tsuji and Koki Uno and Teppei Suzuki and Manabu Ito and Hideki Sudo and Shohei Minami and Toshiaki Kotani and Katsuki Kono and Haruhisa Yanagida and Hiroshi Taneichi and Atsushi Takahashi and Yoshiaki Toyama and Shiro Ikegawa",

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AU - Takahashi, Yohei

AU - Matsumoto, Morio

AU - Karasugi, Tatsuki

AU - Watanabe, Kota

AU - Chiba, Kazuhiro

AU - Kawakami, Noriaki

AU - Tsuji, Taichi

AU - Uno, Koki

AU - Suzuki, Teppei

AU - Ito, Manabu

AU - Sudo, Hideki

AU - Minami, Shohei

AU - Kotani, Toshiaki

AU - Kono, Katsuki

AU - Yanagida, Haruhisa

AU - Taneichi, Hiroshi

AU - Takahashi, Atsushi

AU - Toyama, Yoshiaki

AU - Ikegawa, Shiro

PY - 2011/7

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N2 - Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

AB - Adolescent idiopathic scoliosis (AIS) is a spinal deformity most commonly arising in apparently healthy girls around puberty. AIS has a strong genetic predisposition. Several genetic associations between AIS and single nucleotide polymorphisms (SNPs) have been reported; common SNPs in the genes for matrilin 1 (MATN1), melatonin receptor 1B (MTNR1B), tryptophan hydroxylase 1 (TPH1), and insulin-like growth factor 1 (IGF1) are reported to be associated with AIS in Chinese. However, these associations have not been replicated so far. To confirm the associations, we compared these SNPs with AIS predisposition and curve severity in a population of Japanese females consisting of 798 AIS patients and 1,239 controls. All the subjects were genotyped using the PCR-based Invader assay. We found no association of any of the SNPs with AIS predisposition or curve severity. Considering the statistical power and sample size of the present study, we concluded that these SNPs are not associated with either AIS predisposition or curve severity in Japanese.

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KW - curve severity

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Lack of association between adolescent idiopathic scoliosis and previously reported single nucleotide polymorphisms in MATN1, MTNR1B, TPH1, and IGF1 in a Japanese population

Abstract

Keywords

ASJC Scopus subject areas

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