Language deficits in GRIN2A mutations and Landau–Kleffner syndrome as neural dysrhythmias

Antonio Benítez-Burraco, Koji Hoshi, Elliot Murphy

Research output: Contribution to journalReview articlepeer-review


We review epilepsy-related aphasias in connection with GRIN2A mutations, focusing on acquired childhood epileptic aphasias such as Landau-Kleffner syndrome (LKS). The spontaneous speech of children with LKS exhibits syntactically simplified utterances, severe word finding difficulties, and severe phonological paraphasias. Characterizing LKS as a neural dysrhythmia, we review how EEG abnormalities typically manifested during non-rapid eye movement (NREM) sleep as electrical status epilepticus are related to sleeping disorders partly caused by GRIN2A mutations. Expanding on speculations originally put forward by Landau & Kleffner, 1957, we explore how neural processes such as sharp-wave ripples, sleep spindles, slow oscillations, and their cross-frequency couplings are necessary for language-related processes which are perturbed in LKS, accounting in part for the linguistic profile of epileptic aphasias.

Original languageEnglish
Article number101139
JournalJournal of Neurolinguistics
Publication statusPublished - 2023 Aug


  • Epileptic aphasia
  • GRIN2A mutation
  • Landau-kleffner syndrome
  • Neural dysrhythmia

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Arts and Humanities (miscellaneous)
  • Linguistics and Language
  • Cognitive Neuroscience


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