Laser-driven short-duration heating angioplasty: Chronic artery lumen patency and histology in porcine iliac artery

Natsumi Shimazaki, Mie Kunio, Sho Naruse, Tsunenori Arai, Masami Sakurada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)


We proposed a short-duration heating balloon angioplasty. We designed a prototype short-duration heating balloon catheter that can heat artery media to 60-70°C within 15-25 s with a combination of laser-driven heat generation and continuous fluid irrigation in the balloon. The purpose of this study was to investigate chronic artery lumen patency as well as histological alteration of artery wall after the short-duration heating balloon dilatation with porcine healthy iliac artery. The short-term heating balloon dilated sites were angiographically patent in acute (1 hour) and in chronic phases (1 and 4 weeks). One week after the dilatation, smooth muscle cells (SMCs) density in the artery media measured from H&E-stained specimens was approx. 20% lower than that in the reference artery. One and four weeks after the dilatations, normal structure of artery adventitia was maintained without any incidence of thermal injury. Normal lamellar structure of the artery media was also maintained. We found that the localized heating restricted to artery media by the short-duration heating could maintain adventitial function and artery normal structure in chronic phase.

Original languageEnglish
Title of host publicationPhotonic Therapeutics and Diagnostics VIII
Publication statusPublished - 2012
Externally publishedYes
EventPhotonic Therapeutics and Diagnostics VIII - San Francisco, CA, United States
Duration: 2012 Jan 212012 Jan 24

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
ISSN (Print)1605-7422


OtherPhotonic Therapeutics and Diagnostics VIII
Country/TerritoryUnited States
CitySan Francisco, CA


  • Artery histology
  • Balloon angioplasty
  • Thermal angioplasty

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging


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