Laser-induced stress wave-assisted gene transfection with cationic liposome

Mitsuhiro Terakawa, Risa Otsuka, Shunichi Sato, Yasushi Satoh, Kunio Takishima, Hiroshi Ashida, Hideyuki Okano, Minoru Obara

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We showed that efficiency of gene transfer using laser-induced stress waves (LISWs) can be drastically enhanced by modifying plasmid DNA with cationic liposome. Cultured NIH 3T3 cells were covered with a suspension including plasmid DNA that had been modified with Lipofectamine, and a laser target was placed over the suspension. The cells were exposed to stress waves generated by irradiation of the laser target with 6-ns laser pulses. The cells showed a significantly higher transfection efficiency compared with that of cells treated with LISWs alone or Lipofectamine alone.

Original languageEnglish
Pages (from-to)L1243-L1245
JournalJapanese Journal of Applied Physics, Part 2: Letters
Issue number45-49
Publication statusPublished - 2007 Dec 14


  • Cationic liposome
  • Gene delivery
  • Gene therapy
  • Laser
  • Nonviral vectors

ASJC Scopus subject areas

  • General Engineering
  • General Physics and Astronomy


Dive into the research topics of 'Laser-induced stress wave-assisted gene transfection with cationic liposome'. Together they form a unique fingerprint.

Cite this