Lead accumulation as possible risk factor for primary open-angle glaucoma

Kenya Yuki, Murat Dogru, Yutaka Imamura, Itaru Kimura, Yuichiro Ohtake, Kazuo Tsubota

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26 Citations (Scopus)


We evaluated the association between hair lead concentrations and primary open-angle glaucoma. Ninety-eight Japanese patients (40 males, 58 females; average age 57.6±10.8 years) with primary open-angle glaucoma and control subjects (131 males, 114 females; average age 56.0±12.8 years) were recruited in this study. Hair lead levels were measured by inductively coupled plasma mass spectrometry. Hair lead concentrations between primary open-angle glaucoma and control groups were compared using Mann-Whitney U test. As a subgroup analysis, we compared hair lead concentrations between low-tension glaucoma, high-tension glaucoma, and control groups using one-factor analysis of variance. Lead accumulation levels were significantly higher in the female subjects with primary open-angle glaucoma compared to the control group (P=0.03). Lead accumulation levels were significantly higher in female patients with low intraocular pressure compared to control group 2 (P=0.02). A higher hair lead level, which reflects the total body burden of lead, was observed to be associated with primary open-angle glaucoma in females especially with low-tension glaucoma. Accumulation of lead may be an unrecognized risk factor of non-pressure-dependent glaucomatous optic neuropathy.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiological Trace Element Research
Issue number1-3
Publication statusPublished - 2009 Jan


  • Hair
  • Inductively coupled plasma mass spectrometry
  • Lead
  • Neurotoxicity
  • Primary open-angle glaucoma

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Clinical Biochemistry
  • Biochemistry, medical
  • Inorganic Chemistry


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