Leumorphin is a potent inhibitor of vasopressin secretion.

T. Yamada; K. Nakao; H. Itoh; N. Morii; S. Shiono; M. Sakamoto; A. Sugawara; Y. Saito; G. Katsuura; M. Eigyo

Leumorphin is a potent inhibitor of vasopressin secretion.

T. Yamada, K. Nakao, H. Itoh, N. Morii, S. Shiono, M. Sakamoto, A. Sugawara, Y. Saito, G. Katsuura, M. Eigyo

Research output: Contribution to journal › Article › peer-review

Abstract

The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.

Original language	English
Pages (from-to)	335-338
Number of pages	4
Journal	NIDA research monograph
Volume	75
Publication status	Published - 1986
Externally published	Yes

ASJC Scopus subject areas

Medicine (miscellaneous)

Cite this

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title = "Leumorphin is a potent inhibitor of vasopressin secretion.",

abstract = "The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.",

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T1 - Leumorphin is a potent inhibitor of vasopressin secretion.

AU - Yamada, T.

AU - Nakao, K.

AU - Itoh, H.

AU - Morii, N.

AU - Shiono, S.

AU - Sakamoto, M.

AU - Sugawara, A.

AU - Saito, Y.

AU - Katsuura, G.

AU - Eigyo, M.

N1 - Copyright: This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

PY - 1986

Y1 - 1986

N2 - The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.

AB - The effects of intracerebroventricular (i.c.v.) injection of leumorphin on the vasopressin secretion induced by angiotensin II or dehydration were studied in conscious unrestrained rats. The vasopressin secretion induced by angiotensin II (100 pmol) was significantly inhibited by the simultaneous injection of leumorphin (6 pmol-600 pmol) in a dose-dependent manner. In 72-hour water-deprived rats, the i.c.v. injection of leumorphin (60 pmol or 600 pmol) significantly suppressed the vasopressin secretion dose-dependently. These results suggest that leumorphin is involved in the regulation of the vasopressin secretion.

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ER -

Leumorphin is a potent inhibitor of vasopressin secretion.

Abstract

ASJC Scopus subject areas

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