Light propagation analysis for fluorescence measurements of a molecular probe in the brain

Kota Asai, Takuya Togashi, Eiji Okada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Light propagation in the slab head model that consists of five types of tissues was calculated to estimate the fluorescent intensity emerged from a molecular probe in the brain by a Monte Carlo simulation. The thickness of the scalp, skull and cerebrospinal fluid layer was varied to analyze the influence of the thickness of the superficial tissues on the fluorescent intensity detected on the scalp surface. The fluorescent intensity is exponentially reduced with increasing the depth of the brain surface. The thickness of the cerebrospinal fluid layer more significantly affects the fluorescent intensity than that of the scalp and skull.

Original languageEnglish
Title of host publicationBiomedical Imaging and Sensing Conference
EditorsYasuhiro Awatsuji, Osamu Matoba, Yoshihisa Aizu, Toyohiko Yatagai
PublisherSPIE
ISBN (Electronic)9781510610033
DOIs
Publication statusPublished - 2017
Event3rd Biomedical Imaging and Sensing Conference - Yokohama, Japan
Duration: 2017 Apr 192017 Apr 21

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume10251
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

Other3rd Biomedical Imaging and Sensing Conference
Country/TerritoryJapan
CityYokohama
Period17/4/1917/4/21

Keywords

  • Fluorescence Measurement
  • Light Propagation
  • Optical Diagnosis

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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