Lipase-catalyzed ring-opening polymerization of lactide

Shuichi Matsumura, Kimihiro Mabuchi, Kazunobu Toshima

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)


The six-membered lactide was polymerized using the ring-opening polymerization with lipase as a catalyst at a temperature between 80 and 130°C in bulk to yield the corresponding polylactide with weight-average molecular weights of up to 126000. The most preferable conditions with respect to the molecular weight of the polylactide are the bulk polymerization using lipase PS at a temperature of 100°C. The D,L-lactide gave higher molecular weight compared to the D,D- and L,L-lactide.

Original languageEnglish
Pages (from-to)477-482
Number of pages6
JournalMacromolecular Rapid Communications
Issue number6
Publication statusPublished - 1997 Jun

ASJC Scopus subject areas

  • Organic Chemistry
  • Polymers and Plastics
  • Materials Chemistry


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