Lipase-mediated efficient preparation of both enantiomers of 2-acetoxytetracosanoic acid, the intermediate for sphingolipid synthesis

Takeshi Sugai; Hiromichi Ohta

doi:10.1016/0040-4039(91)85040-C

Lipase-mediated efficient preparation of both enantiomers of 2-acetoxytetracosanoic acid, the intermediate for sphingolipid synthesis

Takeshi Sugai, Hiromichi Ohta

School of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

A solvent system of vinyl acetate-tetrahydrofuran at refluxing temperature was quite effective to perform enzymatic transesterification of highly crystalline substrate, such as 2-hydroxytetracosanoic acid a representative type of long-chain α-hydroxy acid. In that case, catalytic amount of di-t-butyl p-cresol (BHT) was essential as a polymerization inhibitor for vinyl acetate.

Original language	English
Pages (from-to)	7063-7064
Number of pages	2
Journal	Tetrahedron Letters
Volume	32
Issue number	48
DOIs	https://doi.org/10.1016/0040-4039(91)85040-C
Publication status	Published - 1991 Nov 25

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/0040-4039(91)85040-C

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abstract = "A solvent system of vinyl acetate-tetrahydrofuran at refluxing temperature was quite effective to perform enzymatic transesterification of highly crystalline substrate, such as 2-hydroxytetracosanoic acid a representative type of long-chain α-hydroxy acid. In that case, catalytic amount of di-t-butyl p-cresol (BHT) was essential as a polymerization inhibitor for vinyl acetate.",

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Lipase-mediated efficient preparation of both enantiomers of 2-acetoxytetracosanoic acid, the intermediate for sphingolipid synthesis

Abstract

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