TY - JOUR
T1 - Lipid Conjugates as Ligands for the C-type Lectin Receptor Mincle
AU - Matsumaru, Takanori
N1 - Funding Information:
This work is supported by KAKENHI 20K05733 Grant-in-
Publisher Copyright:
© 2022 FCCA (Forum: Carbohydrates Coming of Age).
PY - 2022
Y1 - 2022
N2 - C-type lectin receptors (CLRs), a class of pattern recognition receptors, are expressed on immune cell surfaces and regulate innate immunity by recognizing microbial or endogenous substances. Mincle, a CLR, recognizes various lipid conjugated ligands, such as glycolipids. In this review, recently synthetically accessed natural Mincle ligand-lipid conjugates as well as their analogues are discussed.
AB - C-type lectin receptors (CLRs), a class of pattern recognition receptors, are expressed on immune cell surfaces and regulate innate immunity by recognizing microbial or endogenous substances. Mincle, a CLR, recognizes various lipid conjugated ligands, such as glycolipids. In this review, recently synthetically accessed natural Mincle ligand-lipid conjugates as well as their analogues are discussed.
KW - C-type lectin receptor
KW - glycolipids
KW - innate immunity
KW - lipid conjugates
KW - Mincle
UR - http://www.scopus.com/inward/record.url?scp=85131568935&partnerID=8YFLogxK
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U2 - 10.4052/tigg.2029.1E
DO - 10.4052/tigg.2029.1E
M3 - Short survey
AN - SCOPUS:85131568935
SN - 0915-7352
VL - 34
SP - E55-E59
JO - Trends in Glycoscience and Glycotechnology
JF - Trends in Glycoscience and Glycotechnology
IS - 199
ER -